Situated in Venice's Dorsoduro district, the neo-Gothic Sina Centurion Palace overlooks the Grand Canal from the 19th-century Palazzo Genovese. During its restoration, ancient remains — including a 7th-century stone building and a rare coin — were unearthed, revealing layers of Venetian history. With landmarks like the Basilica of Santa Maria della Salute, Punta della Dogana and the Peggy Guggenheim Museum nearby, the hotel appeals to art enthusiasts and history lovers. A crossing over the Accademia Bridge leads to St. Mark's Square, making it convenient for exploring the city's iconic sites.

The hotel offers 50 rooms and suites that reflect Venice's charm with a modern touch. Each space features a blend of vibrant colors, fine fabrics and designer furnishings. Many rooms have gold-leaf bathrooms with either a bathtub or a shower. Accommodations range from Classic Rooms overlooking the internal courtyard to the Presidential Suite with a neo-Gothic balcony and panoramic views of the Grand Canal. Guests can choose rooms with city, garden or canal views. For couples seeking a romantic getaway, the suites with private terraces offer stunning canal vistas, while families or groups might appreciate the spacious suites with mezzanine levels and high ceilings.

Located in Venice's Dorsoduro neighborhood on the Grand Canal, Sina Centurion Palace is accessible via a 30-minute water taxi ride from Venice Marco Polo Airport directly to the hotel's private dock. Alternatively, the Alilaguna Orange Line stops at Salute, a short walk from the hotel. Santa Lucia Station is approximately 20 minutes away by vaporetto. Major attractions like the Peggy Guggenheim Museum and St. Mark's Square are within walking distance.