Standing since 1272, this 5-star retreat embodies the essence of Venice, offering panoramic views of the lagoon and Isola di San Giorgio Maggiore. Designed by Patricia Urquiola, the hotel showcases historic architecture enhanced by contemporary design elements like Murano glass accents, Istrian stone facades, and preserved frescoes that celebrate the city's artistic heritage. With an intimate atmosphere and personalized service, the hotel is ideal for couples seeking a romantic getaway or art enthusiasts attending the nearby Venice Biennale.

The hotel offers 66 rooms and suites that reflect Venice's storied past while providing modern amenities. Each room features contemporary finishes alongside refined woodwork and marble accents, creating inviting spaces. Many accommodations have large windows or terraces overlooking internal courtyards, Rio Ca' di Dio, or the Venetian lagoon. Couples might enjoy the Deluxe rooms with Murano glass lamps, while guests desiring expansive views can choose the Suite Altana with its private rooftop terrace overlooking the city.

Located along the lagoon, Ca' di Dio is approximately 30 minutes from Venice Marco Polo International Airport. Guests can reach the hotel via private water taxi directly to the hotel's docking on Rio dell’Arsenale or by public water transport followed by a short walk. Venezia Santa Lucia railway station is about 15 minutes away. Parking is available at Piazzale Roma (reservation recommended) for those driving into the city. The hotel is within walking distance of the Biennale and several landmarks.