21c Museum Hotel Louisville

Louisville, Kentucky, United States
4-star hotel
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Travelers drawn to immersive art experiences and unique cultural offerings will find this hotel captivating.

Rooms and suites

Designed by Deborah Berke Partners, the guest rooms at 21c Louisville showcase modern design alongside historic elements. High ceilings and large windows fill the spaces with natural light and select rooms feature exposed brick walls that reflect the building's past. Outfitted with custom-designed furniture, luxury bedding and Malin + Goetz bath amenities, each room provides a tranquil retreat amid the hotel's vibrant energy. Guests seeking a truly unique stay can book the Asleep in the Cyclone room, immersed within a multicolored, site-specific art installation — a memorable experience for art enthusiasts.

Amenities and experiences
Dining

Proof on Main — locally sourced ingredients, contemporary flavors and over 120 Kentucky Bourbons, including exclusive bottlings.

Art exhibitions and cultural programming

Over 9,000 square feet of gallery space with rotating exhibitions and installations, plus weekly guided tours and special events.

Wellness

On-site sauna and steam room, personalized massage treatments.

Fitness

24-hour fitness center.

Museum shop

On-site shop featuring items that reflect the hotel's artistic spirit.

Pet-friendly accommodations

The hotel welcomes pets up to 50 pounds (fees may apply).

How to get here

Positioned in downtown Louisville, the hotel is a 15-minute drive from Louisville International Airport (SDF). It's within walking distance of attractions like the Louisville Slugger Museum & Factory, the Muhammad Ali Center and the Kentucky Science Center. Valet parking and rental cars can be arranged.

21c-museum-hotel-louisville
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Address700 W Main Street, Louisville, Kentucky, United States
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